Assay Detail
Functional
CHEMBL951613
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NDK infected in U87.CD4 cells expressing human CXCR4 H281A mutant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | U87.CD4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.43 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477121 | — | — | 1 | 7.43 |
| CHEMBL18442 | PLERIXAFOR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477121 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL18442 | PLERIXAFOR | IC50 | < | 1.9 | nM | - |