Assay Detail
Binding
CHEMBL951786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGFR autophosphorylation in mouse Swiss 3T3 fibroblast by immunoblotting
30
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor (CHEMBL2096980) ↗| Type | PROTEIN COMPLEX |
| Organism | Mus musculus |
Publication
Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides: a SAR study on the bioisosterism of pyrimidine and imidazole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.98 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20926 | — | — | 1 | 7.00 |
| CHEMBL473116 | — | — | 1 | 6.70 |
| CHEMBL462643 | — | — | 2 | 6.70 |
| CHEMBL462626 | — | — | 1 | 6.52 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 6.52 |
| CHEMBL474525 | — | — | 1 | 6.52 |
| CHEMBL472921 | — | — | 1 | 6.52 |
| CHEMBL516043 | — | — | 1 | 6.40 |
| CHEMBL523953 | — | — | 1 | 6.22 |
| CHEMBL514457 | — | — | 1 | 6.22 |
| CHEMBL516222 | — | — | 1 | 5.80 |
| CHEMBL473115 | — | — | 1 | 5.75 |
| CHEMBL473322 | — | — | 1 | 5.66 |
| CHEMBL514458 | — | — | 1 | 5.33 |
| CHEMBL462625 | — | — | 1 | 5.23 |
| CHEMBL473321 | — | — | 1 | 5.19 |
| CHEMBL474526 | — | — | 1 | 5.19 |
| CHEMBL517443 | — | — | 1 | 5.15 |
| CHEMBL423288 | — | — | 1 | 4.30 |
| CHEMBL472920 | — | — | 1 | - |
| CHEMBL472926 | — | — | 1 | - |
| CHEMBL462444 | — | — | 1 | - |
| CHEMBL517752 | — | — | 1 | - |
| CHEMBL461740 | — | — | 1 | - |
| CHEMBL472927 | — | — | 1 | - |
| CHEMBL462642 | — | — | 1 | - |
| CHEMBL461927 | — | — | 1 | - |
| CHEMBL461926 | — | — | 1 | - |
| CHEMBL473123 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20926 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL462643 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL462643 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL473116 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL462626 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL941 | IMATINIB | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL474525 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL472921 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL516043 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL523953 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL514457 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL516222 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL473115 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL473322 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL514458 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL462625 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL473321 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL474526 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL517443 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL423288 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL472920 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL473123 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL472927 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL472926 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL462444 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL517752 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL462642 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL461927 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL461926 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL461740 | — | IC50 | > | 30000.0 | nM | - |