Assay Detail

CHEMBL951813

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Binding

Inhibition of sphingosine-1-phosphate lyase in mouse spleen by scintillation counting

ChEMBL ↗

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Target

Sphingosine-1-phosphate lyase 1 (CHEMBL5009) ↗

Open DB target context

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Sphingosine-1-phosphate lyase 1 (CHEMBL5009) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Sphingosine-1-phosphate lyase 1

CHEMBL5009

Anchored from Assay target.

Protein identity Sphingosine-1-phosphate lyase 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Mus musculus
Tissue	Spleen
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Sphingosine-1-phosphate lyase 1 (CHEMBL5009) ↗

Type	SINGLE PROTEIN
Organism	Mus musculus

Publication

Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders.

Bagdanoff JT, Donoviel MS, Nouraldeen A, Tarver J, Fu Q, Carlsen M, Jessop TC, Zhang H, Hazelwood J, Nguyen H, Baugh SD, Gardyan M, Terranova KM, Barbosa J, Yan J, Bednarz M, Layek S, Courtney LF, Taylor J, Digeorge-Foushee AM, Gopinathan S, Bruce D, Smith T, Moran L, O'Neill E, Kramer J, Lai Z, Kimball SD, Liu Q, Sun W, Yu S, Swaffield J, Wilson A, Main A, Carson KG, Oravecz T, Augeri DJ.
J Med Chem (2009) 52 : 3941 -3953
PubMed 19489538 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.68	5.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL491458	—	—	1	5.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL491458	—	IC50	=	2100.0	nM	5.68