Assay Detail
Functional
CHEMBL951835
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 8.34 | 8.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483688 | — | — | 1 | 8.95 |
| CHEMBL486479 | — | — | 1 | 8.79 |
| CHEMBL483469 | — | — | 1 | 8.72 |
| CHEMBL519390 | — | — | 1 | 8.64 |
| CHEMBL484900 | — | — | 1 | 8.49 |
| CHEMBL486688 | — | — | 1 | 8.45 |
| CHEMBL482436 | — | — | 1 | 8.44 |
| CHEMBL519813 | — | — | 1 | 8.35 |
| CHEMBL482648 | — | — | 1 | 8.28 |
| CHEMBL483065 | — | — | 1 | 8.27 |
| CHEMBL212625 | — | — | 1 | 8.00 |
| CHEMBL488541 | — | — | 1 | 7.96 |
| CHEMBL482855 | — | — | 1 | 7.79 |
| CHEMBL486893 | — | — | 1 | 7.63 |
| CHEMBL483261 | — | — | 1 | - |
| CHEMBL482638 | — | — | 1 | - |
| CHEMBL520297 | — | — | 1 | - |
| CHEMBL520830 | — | — | 1 | - |
| CHEMBL484899 | — | — | 1 | - |
| CHEMBL486478 | — | — | 1 | - |
| CHEMBL520617 | — | — | 1 | - |
| CHEMBL518972 | — | — | 1 | - |
| CHEMBL483487 | — | — | 1 | - |
| CHEMBL486282 | — | — | 1 | - |
| CHEMBL519253 | — | — | 1 | - |
| CHEMBL520899 | — | — | 1 | - |
| CHEMBL486281 | — | — | 1 | - |
| CHEMBL488542 | — | — | 1 | - |
| CHEMBL486481 | — | — | 1 | - |
| CHEMBL519556 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483688 | — | IC50 | = | 1.13 | nM | 8.95 |
| CHEMBL486479 | — | IC50 | = | 1.62 | nM | 8.79 |
| CHEMBL483469 | — | IC50 | = | 1.91 | nM | 8.72 |
| CHEMBL519390 | — | IC50 | = | 2.29 | nM | 8.64 |
| CHEMBL484900 | — | IC50 | = | 3.23 | nM | 8.49 |
| CHEMBL486688 | — | IC50 | = | 3.56 | nM | 8.45 |
| CHEMBL482436 | — | IC50 | = | 3.64 | nM | 8.44 |
| CHEMBL519813 | — | IC50 | = | 4.49 | nM | 8.35 |
| CHEMBL482648 | — | IC50 | = | 5.26 | nM | 8.28 |
| CHEMBL483065 | — | IC50 | = | 5.34 | nM | 8.27 |
| CHEMBL212625 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL488541 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL482855 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL486893 | — | IC50 | = | 23.4 | nM | 7.63 |
| CHEMBL483261 | — | IC50 | - | — | - | |
| CHEMBL482638 | — | IC50 | - | — | - | |
| CHEMBL520297 | — | IC50 | - | — | - | |
| CHEMBL520830 | — | IC50 | - | — | - | |
| CHEMBL484899 | — | IC50 | - | — | - | |
| CHEMBL486478 | — | IC50 | - | — | - | |
| CHEMBL520617 | — | IC50 | - | — | - | |
| CHEMBL518972 | — | IC50 | - | — | - | |
| CHEMBL483487 | — | IC50 | - | — | - | |
| CHEMBL486282 | — | IC50 | - | — | - | |
| CHEMBL519253 | — | IC50 | - | — | - | |
| CHEMBL520899 | — | IC50 | - | — | - | |
| CHEMBL486281 | — | IC50 | - | — | - | |
| CHEMBL488542 | — | IC50 | - | — | - | |
| CHEMBL486481 | — | IC50 | - | — | - | |
| CHEMBL519556 | — | IC50 | - | — | - |