Assay Detail
Binding
CHEMBL951931
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Inhibition of Lck by HTRF assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 8.28 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385937 | — | — | 1 | 9.70 |
| CHEMBL407063 | — | — | 1 | 9.52 |
| CHEMBL429582 | — | — | 1 | 9.40 |
| CHEMBL408070 | — | — | 1 | 9.30 |
| CHEMBL405666 | — | — | 1 | 9.22 |
| CHEMBL272888 | — | — | 1 | 9.22 |
| CHEMBL271140 | — | — | 1 | 9.10 |
| CHEMBL271141 | — | — | 1 | 8.89 |
| CHEMBL272850 | — | — | 1 | 8.85 |
| CHEMBL405401 | — | — | 1 | 8.82 |
| CHEMBL271154 | — | — | 1 | 8.74 |
| CHEMBL409734 | — | — | 1 | 8.30 |
| CHEMBL271760 | — | — | 1 | 8.30 |
| CHEMBL438016 | — | — | 1 | 8.22 |
| CHEMBL270765 | — | — | 1 | 8.22 |
| CHEMBL409914 | — | — | 1 | 8.15 |
| CHEMBL541726 | — | — | 1 | 8.00 |
| CHEMBL411632 | — | — | 1 | 7.85 |
| CHEMBL411050 | — | — | 1 | 7.85 |
| CHEMBL272902 | — | — | 1 | 7.82 |
| CHEMBL259465 | — | — | 1 | 7.62 |
| CHEMBL271201 | — | — | 1 | 7.32 |
| CHEMBL271375 | — | — | 1 | 7.20 |
| CHEMBL272673 | — | — | 1 | 7.14 |
| CHEMBL259247 | — | — | 1 | 6.62 |
| CHEMBL271372 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385937 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL407063 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL429582 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL408070 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL405666 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL272888 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL271140 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL271141 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL272850 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL405401 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL271154 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL409734 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL271760 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL438016 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL270765 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL409914 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL541726 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL411632 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL411050 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL272902 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL259465 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL271201 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL271375 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL272673 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL259247 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL271372 | — | IC50 | = | 1310.0 | nM | 5.88 |