Compound Detail
CHEMBL409914
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Basic Information
| ChEMBL ID | CHEMBL409914 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BIPPSOZOQMDQPZ-UHFFFAOYSA-N |
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
437.4
MW (Da)
5.85
ALogP
4
HBA
3
HBD
92.9
PSA (Ų)
0.37
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 8.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase Lck CHEMBL258 | IC50 | 8.15 | 8.15 | 7.0 | 1 |
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 7.55 | 7.55 | 28.0 | 1 |
| Angiopoietin-1 receptor CHEMBL4128 | IC50 | 7.03 | 7.03 | 93.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.77 | 6.77 | 169.0 | 1 |
| Lymphocyte CHEMBL612599 | IC50 | 6.69 | 6.69 | 205.0 | 1 |
| Tyrosine-protein kinase JAK3 CHEMBL2148 | IC50 | 5.52 | 5.52 | 3040.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase Lck | IC50 | = | 7.0 | nM | 8.15 | Inhibition of Lck by HTRF assay | 18321037 |
| Mitogen-activated protein kinase 14 | IC50 | = | 28.0 | nM | 7.55 | Inhibition of p38alpha by HTRF assay | 18321037 |
| Angiopoietin-1 receptor | IC50 | = | 93.0 | nM | 7.03 | Inhibition of Tie2 by HTRF assay | 18321037 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 169.0 | nM | 6.77 | Inhibition of KDR by HTRF assay | 18321037 |
| Lymphocyte | IC50 | = | 205.0 | nM | 6.69 | Inhibition of T cell activation in human peripheral blood lymphocytes by mixed l... | 18321037 |
| Tyrosine-protein kinase JAK3 | IC50 | = | 3040.0 | nM | 5.52 | Inhibition of Jak3 by HTRF assay | 18321037 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18321037 | 10.1021/jm7010996 | Tyrosine-protein kinase Lck | 1 |
| 18321037 | 10.1021/jm7010996 | Mitogen-activated protein kinase 14 | 1 |
| 18321037 | 10.1021/jm7010996 | Lymphocyte | 1 |
| 18321037 | 10.1021/jm7010996 | Angiopoietin-1 receptor | 1 |
| 18321037 | 10.1021/jm7010996 | Vascular endothelial growth factor receptor 2 | 1 |
| 18321037 | 10.1021/jm7010996 | Tyrosine-protein kinase JAK3 | 1 |
Data from ChEMBL 36 via Core Engine