Assay Detail
Functional
CHEMBL951936
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of T cell activation in human peripheral blood lymphocytes by mixed lymphocyte reaction
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Lymphocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.96 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385937 | — | — | 1 | 8.05 |
| CHEMBL405401 | — | — | 1 | 8.00 |
| CHEMBL272888 | — | — | 1 | 7.96 |
| CHEMBL408070 | — | — | 1 | 7.82 |
| CHEMBL407063 | — | — | 1 | 7.68 |
| CHEMBL271154 | — | — | 1 | 7.54 |
| CHEMBL429582 | — | — | 1 | 7.37 |
| CHEMBL271141 | — | — | 1 | 7.24 |
| CHEMBL271140 | — | — | 1 | 7.22 |
| CHEMBL272850 | — | — | 1 | 7.11 |
| CHEMBL405666 | — | — | 1 | 7.06 |
| CHEMBL411632 | — | — | 1 | 6.97 |
| CHEMBL271375 | — | — | 1 | 6.80 |
| CHEMBL271760 | — | — | 1 | 6.73 |
| CHEMBL272673 | — | — | 1 | 6.70 |
| CHEMBL409914 | — | — | 1 | 6.69 |
| CHEMBL409734 | — | — | 1 | 6.40 |
| CHEMBL541726 | — | — | 1 | 6.26 |
| CHEMBL259465 | — | — | 1 | 6.09 |
| CHEMBL438016 | — | — | 1 | 6.08 |
| CHEMBL270765 | — | — | 1 | 6.03 |
| CHEMBL411050 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385937 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL405401 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL272888 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL408070 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL407063 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL271154 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL429582 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL271141 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL271140 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL272850 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL405666 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL411632 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL271375 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL271760 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL272673 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL409914 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL409734 | — | IC50 | = | 399.0 | nM | 6.40 |
| CHEMBL541726 | — | IC50 | = | 555.0 | nM | 6.26 |
| CHEMBL259465 | — | IC50 | = | 821.0 | nM | 6.09 |
| CHEMBL438016 | — | IC50 | = | 836.0 | nM | 6.08 |
| CHEMBL270765 | — | IC50 | = | 928.0 | nM | 6.03 |
| CHEMBL411050 | — | IC50 | = | 3920.0 | nM | 5.41 |