Assay Detail
Binding
CHEMBL952122
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Inhibition of p38alpha
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of kinase inhibitors by high-throughput docking and scoring based on a transferable linear interaction energy model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 8.38 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327959 | — | — | 1 | 10.00 |
| CHEMBL328614 | — | — | 1 | 10.00 |
| CHEMBL97227 | — | — | 1 | 10.00 |
| CHEMBL327746 | — | — | 1 | 9.89 |
| CHEMBL319556 | — | — | 1 | 9.70 |
| CHEMBL94825 | — | — | 1 | 9.70 |
| CHEMBL327987 | — | — | 1 | 9.30 |
| CHEMBL96432 | — | — | 1 | 9.22 |
| CHEMBL96763 | — | — | 1 | 9.05 |
| CHEMBL94556 | — | — | 1 | 9.00 |
| CHEMBL96225 | — | — | 1 | 8.96 |
| CHEMBL96487 | — | — | 1 | 8.85 |
| CHEMBL94444 | — | — | 1 | 8.82 |
| CHEMBL327217 | — | — | 1 | 8.62 |
| CHEMBL94417 | — | — | 1 | 8.59 |
| CHEMBL94770 | — | — | 1 | 8.52 |
| CHEMBL96632 | — | — | 1 | 8.22 |
| CHEMBL94495 | — | — | 1 | 8.15 |
| CHEMBL94547 | — | — | 1 | 8.15 |
| CHEMBL94783 | — | — | 1 | 7.96 |
| CHEMBL94377 | — | — | 1 | 7.96 |
| CHEMBL96091 | — | — | 1 | 7.96 |
| CHEMBL328252 | — | — | 1 | 7.66 |
| CHEMBL421194 | — | — | 1 | 7.52 |
| CHEMBL316337 | — | — | 1 | 7.36 |
| CHEMBL97579 | — | — | 1 | 7.36 |
| CHEMBL330358 | — | — | 1 | 7.33 |
| CHEMBL421566 | — | — | 1 | 7.17 |
| CHEMBL94852 | — | — | 1 | 7.10 |
| CHEMBL94719 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327959 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL97227 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL328614 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL327746 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL319556 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL94825 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL327987 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL96432 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL96763 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL94556 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL96225 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL96487 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL94444 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL327217 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL94417 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL94770 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL96632 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL94495 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL94547 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL94783 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL94377 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL96091 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL328252 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL421194 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL316337 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL97579 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL330358 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL421566 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL94852 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL94719 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL328752 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL328274 | — | IC50 | = | 320.0 | nM | 6.50 |