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Assay Detail

CHEMBL952125

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Suppression of TNFalpha production in LPS-stimulated whole blood
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Tissue Blood
Confidence 1 — Organism
Curated By Autocuration

Target

Blood (CHEMBL613416)
Type TISSUE
Organism Homo sapiens

Publication

Discovery of kinase inhibitors by high-throughput docking and scoring based on a transferable linear interaction energy model.
Kolb P, Huang D, Dey F, Caflisch A.
J Med Chem (2008) 51 : 1179 -1188
PubMed 18271520 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 8.39 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL327959 1 9.15
CHEMBL327746 1 9.15
CHEMBL328614 1 9.00
CHEMBL319556 1 8.89
CHEMBL97227 1 8.85
CHEMBL94825 1 8.80
CHEMBL96763 1 8.70
CHEMBL96487 1 8.54
CHEMBL96225 1 8.42
CHEMBL96345 1 8.40
CHEMBL327987 1 8.36
CHEMBL96432 1 8.35
CHEMBL328242 1 8.25
CHEMBL271528 1 8.15
CHEMBL271750 1 8.12
CHEMBL94417 1 8.11
CHEMBL316604 1 8.00
CHEMBL94444 1 7.94
CHEMBL419140 1 7.91
CHEMBL270956 1 7.57
CHEMBL327217 1 7.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL327959 IC50 = 0.7 nM 9.15
CHEMBL327746 IC50 = 0.7 nM 9.15
CHEMBL328614 IC50 = 1.0 nM 9.00
CHEMBL319556 IC50 = 1.3 nM 8.89
CHEMBL97227 IC50 = 1.4 nM 8.85
CHEMBL94825 IC50 = 1.6 nM 8.80
CHEMBL96763 IC50 = 2.0 nM 8.70
CHEMBL96487 IC50 = 2.9 nM 8.54
CHEMBL96225 IC50 = 3.8 nM 8.42
CHEMBL96345 IC50 = 4.0 nM 8.40
CHEMBL327987 IC50 = 4.4 nM 8.36
CHEMBL96432 IC50 = 4.5 nM 8.35
CHEMBL328242 IC50 = 5.6 nM 8.25
CHEMBL271528 IC50 = 7.0 nM 8.15
CHEMBL271750 IC50 = 7.6 nM 8.12
CHEMBL94417 IC50 = 7.8 nM 8.11
CHEMBL316604 IC50 = 10.1 nM 8.00
CHEMBL94444 IC50 = 11.4 nM 7.94
CHEMBL419140 IC50 = 12.2 nM 7.91
CHEMBL270956 IC50 = 27.1 nM 7.57
CHEMBL327217 IC50 = 26.8 nM 7.57