Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL952131

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of EGFR
ChEMBL ↗
128
Total Activities
128
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Epidermal growth factor receptor (CHEMBL203) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of kinase inhibitors by high-throughput docking and scoring based on a transferable linear interaction energy model.
Kolb P, Huang D, Dey F, Caflisch A.
J Med Chem (2008) 51 : 1179 -1188
PubMed 18271520 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 128 7.74 10.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL328106 — — 1 10.14
CHEMBL328216 — — 1 9.92
CHEMBL418967 — — 1 9.76
CHEMBL93032 — — 1 9.76
CHEMBL270696 — — 1 9.61
CHEMBL316064 — — 1 9.61
CHEMBL53426 — — 1 9.60
CHEMBL271122 — — 1 9.55
CHEMBL7917 TYRPHOSTIN AG-1478 — 1 9.50
CHEMBL272865 — — 1 9.29
CHEMBL408399 — — 1 9.21
CHEMBL92937 — — 1 9.16
CHEMBL299622 — — 1 9.11
CHEMBL294475 — — 1 9.09
CHEMBL96065 — — 1 9.05
CHEMBL272187 — — 1 9.04
CHEMBL270695 — — 1 9.03
CHEMBL53777 — — 1 9.02
CHEMBL427832 — — 1 8.92
CHEMBL270895 — — 1 8.85
CHEMBL405771 — — 1 8.82
CHEMBL53831 — — 1 8.82
CHEMBL271334 — — 1 8.72
CHEMBL299881 — — 1 8.63
CHEMBL271328 — — 1 8.63
CHEMBL53299 — — 1 8.63
CHEMBL408397 — — 1 8.58
CHEMBL53062 — — 1 8.58
CHEMBL417420 — — 1 8.53
CHEMBL416307 — — 1 8.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL328106 — IC50 = 0.07244 nM 10.14
CHEMBL328216 — IC50 = 0.1202 nM 9.92
CHEMBL93032 — IC50 = 0.1738 nM 9.76
CHEMBL418967 — IC50 = 0.1738 nM 9.76
CHEMBL316064 — IC50 = 0.2455 nM 9.61
CHEMBL270696 — IC50 = 0.2455 nM 9.61
CHEMBL53426 — IC50 = 0.2512 nM 9.60
CHEMBL271122 — IC50 = 0.2818 nM 9.55
CHEMBL7917 TYRPHOSTIN AG-1478 IC50 = 0.3162 nM 9.50
CHEMBL272865 — IC50 = 0.5129 nM 9.29
CHEMBL408399 — IC50 = 0.6166 nM 9.21
CHEMBL92937 — IC50 = 0.6918 nM 9.16
CHEMBL299622 — IC50 = 0.7762 nM 9.11
CHEMBL294475 — IC50 = 0.8128 nM 9.09
CHEMBL96065 — IC50 = 0.8913 nM 9.05
CHEMBL272187 — IC50 = 0.912 nM 9.04
CHEMBL270695 — IC50 = 0.9333 nM 9.03
CHEMBL53777 — IC50 = 0.955 nM 9.02
CHEMBL427832 — IC50 = 1.202 nM 8.92
CHEMBL270895 — IC50 = 1.413 nM 8.85
CHEMBL405771 — IC50 = 1.514 nM 8.82
CHEMBL53831 — IC50 = 1.514 nM 8.82
CHEMBL271334 — IC50 = 1.905 nM 8.72
CHEMBL271328 — IC50 = 2.344 nM 8.63
CHEMBL53299 — IC50 = 2.344 nM 8.63
CHEMBL299881 — IC50 = 2.344 nM 8.63
CHEMBL53062 — IC50 = 2.63 nM 8.58
CHEMBL408397 — IC50 = 2.63 nM 8.58
CHEMBL417420 — IC50 = 2.951 nM 8.53
CHEMBL416307 — IC50 = 3.02 nM 8.52
CHEMBL53156 — IC50 = 3.162 nM 8.50
CHEMBL405398 — IC50 = 3.236 nM 8.49
CHEMBL410635 — IC50 = 3.236 nM 8.49
CHEMBL433205 — IC50 = 3.311 nM 8.48
CHEMBL271408 — IC50 = 3.548 nM 8.45
CHEMBL96780 — IC50 = 3.802 nM 8.42
CHEMBL94431 — IC50 = 3.802 nM 8.42
CHEMBL51854 — IC50 = 3.802 nM 8.42
CHEMBL52829 — IC50 = 4.074 nM 8.39
CHEMBL50344 — IC50 = 4.074 nM 8.39
CHEMBL52591 — IC50 = 4.365 nM 8.36
CHEMBL50519 — IC50 = 4.365 nM 8.36
CHEMBL93302 — IC50 = 4.786 nM 8.32
CHEMBL271532 — IC50 = 5.012 nM 8.30
CHEMBL271587 — IC50 = 5.495 nM 8.26
CHEMBL272895 — IC50 = 5.495 nM 8.26
CHEMBL410253 — IC50 = 5.623 nM 8.25
CHEMBL63469 — IC50 = 6.607 nM 8.18
CHEMBL92812 — IC50 = 7.079 nM 8.15
CHEMBL272634 — IC50 = 7.244 nM 8.14