Assay Detail
Functional
CHEMBL952403
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Cytotoxicity against human HCT116 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.74 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142918 | rolliniastatin-1 | — | 1 | 9.66 |
| CHEMBL509939 | — | — | 1 | 9.35 |
| CHEMBL606053 | ASIMICIN | — | 1 | 9.29 |
| CHEMBL451402 | — | — | 1 | 9.16 |
| CHEMBL1159657 | BULLATACIN | — | 1 | 8.85 |
| CHEMBL506914 | — | — | 1 | 8.25 |
| CHEMBL446085 | — | — | 1 | 7.75 |
| CHEMBL508255 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142918 | rolliniastatin-1 | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL509939 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL606053 | ASIMICIN | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL451402 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL1159657 | BULLATACIN | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL506914 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL446085 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL508255 | — | IC50 | = | 27.0 | nM | 7.57 |