Assay Detail
ADMET
CHEMBL952865
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Growth inhibition of rat L6 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.46 | 4.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405590 | — | — | 1 | 4.69 |
| CHEMBL406774 | — | — | 1 | 4.35 |
| CHEMBL261776 | — | — | 1 | 4.33 |
| CHEMBL259665 | — | — | 1 | - |
| CHEMBL258503 | — | — | 1 | - |
| CHEMBL258717 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405590 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL406774 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL261776 | — | IC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL259665 | — | IC50 | = | 265200.0 | nM | - |
| CHEMBL258503 | — | IC50 | - | — | - | |
| CHEMBL258717 | — | IC50 | - | — | - |