Assay Detail
Functional
CHEMBL952895
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Antiviral activity against lamivudine-adefovir-resistant HBV with reverse transcriptase L180M/M204V/N236T mutant assessed as inhibition of replication
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.72 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314362 | ENTECAVIR | 4.0 | 1 | 5.30 |
| CHEMBL298845 | — | — | 1 | 5.24 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 4.34 |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | 4.0 | 1 | 4.00 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314362 | ENTECAVIR | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL298845 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 45500.0 | nM | 4.34 |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL141 | LAMIVUDINE | EC50 | > | 100000.0 | nM | - |