Assay Detail
Binding
CHEMBL953082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ADAMTS5
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
A disintegrin and metalloproteinase with thrombospondin motifs 5 (CHEMBL2285) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.72 | 5.72 |
| IC50 | 2 | 6.08 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401435 | — | — | 1 | 6.19 |
| CHEMBL231740 | — | — | 1 | 5.96 |
| CHEMBL253275 | — | — | 1 | 5.72 |
| CHEMBL495502 | — | — | 1 | 5.72 |
| CHEMBL207305 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401435 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL231740 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL253275 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL495502 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL207305 | — | Ki | = | 1900.0 | nM | 5.72 |