Assay Detail
Binding
CHEMBL953083
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Inhibition of ADAM10
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Disintegrin and metalloproteinase domain-containing protein 10 (CHEMBL5028) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.05 | 7.66 |
| Ki | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434567 | — | — | 1 | 7.66 |
| CHEMBL491643 | — | — | 1 | 7.58 |
| CHEMBL497985 | — | — | 1 | 7.01 |
| CHEMBL484261 | — | — | 1 | 5.96 |
| CHEMBL253275 | — | — | 1 | - |
| CHEMBL495502 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434567 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL491643 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL497985 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL484261 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL253275 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL495502 | — | Ki | > | 3000.0 | nM | - |