Assay Detail
Binding
CHEMBL953112
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of pig TACE
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3332) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.56 | 9.00 |
| Ki | 5 | 9.13 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL252893 | — | — | 1 | 9.82 |
| CHEMBL207305 | — | — | 1 | 9.46 |
| CHEMBL148169 | — | — | 1 | 9.25 |
| CHEMBL402393 | — | — | 1 | 9.00 |
| CHEMBL253275 | — | — | 1 | 8.85 |
| CHEMBL395880 | — | — | 1 | 8.70 |
| CHEMBL495502 | — | — | 1 | 8.55 |
| CHEMBL325163 | — | — | 1 | 8.55 |
| CHEMBL496527 | — | — | 1 | 8.21 |
| CHEMBL228320 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL252893 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL207305 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL148169 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL402393 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL253275 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL395880 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL495502 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL325163 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL496527 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL228320 | — | IC50 | = | 9.0 | nM | 8.05 |