Assay Detail
Functional
CHEMBL953182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B in human MT4 cells assessed as inhibition of viral-induced cytopathic effect by MTT method
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Combination of non-natural D-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV protease inhibitors have high efficacy in mutant HIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 35 | 7.35 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509787 | — | — | 1 | 8.19 |
| CHEMBL455816 | — | — | 1 | 8.03 |
| CHEMBL449945 | — | — | 1 | 7.92 |
| CHEMBL230484 | — | — | 1 | 7.89 |
| CHEMBL449552 | — | — | 1 | 7.89 |
| CHEMBL449213 | — | — | 1 | 7.82 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 7.80 |
| CHEMBL504713 | — | — | 1 | 7.77 |
| CHEMBL448032 | — | — | 1 | 7.77 |
| CHEMBL448021 | — | — | 1 | 7.77 |
| CHEMBL502912 | — | — | 1 | 7.75 |
| CHEMBL503829 | — | — | 1 | 7.70 |
| CHEMBL449836 | — | — | 1 | 7.68 |
| CHEMBL414640 | — | — | 1 | 7.66 |
| CHEMBL509400 | — | — | 1 | 7.55 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 7.44 |
| CHEMBL510136 | — | — | 1 | 7.40 |
| CHEMBL462726 | — | — | 1 | 7.33 |
| CHEMBL505525 | — | — | 1 | 7.29 |
| CHEMBL449028 | — | — | 1 | 7.23 |
| CHEMBL452953 | — | — | 1 | 7.21 |
| CHEMBL447770 | — | — | 1 | 7.09 |
| CHEMBL485911 | — | — | 1 | 7.09 |
| CHEMBL445434 | — | — | 1 | 7.03 |
| CHEMBL396464 | — | — | 1 | 6.99 |
| CHEMBL508278 | — | — | 1 | 6.98 |
| CHEMBL504690 | — | — | 1 | 6.93 |
| CHEMBL502856 | — | — | 1 | 6.90 |
| CHEMBL500369 | — | — | 1 | 6.82 |
| CHEMBL447212 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509787 | — | EC50 | = | 6.4 | nM | 8.19 |
| CHEMBL455816 | — | EC50 | = | 9.3 | nM | 8.03 |
| CHEMBL449945 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL230484 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL449552 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL449213 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL504713 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL448032 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL448021 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL502912 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL503829 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL449836 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL414640 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL509400 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL163 | RITONAVIR | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL510136 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL462726 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL505525 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL449028 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL452953 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL447770 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL485911 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL445434 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL396464 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL508278 | — | EC50 | = | 105.0 | nM | 6.98 |
| CHEMBL504690 | — | EC50 | = | 117.0 | nM | 6.93 |
| CHEMBL502856 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL500369 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL447212 | — | EC50 | = | 169.0 | nM | 6.77 |
| CHEMBL475133 | — | EC50 | = | 203.0 | nM | 6.69 |
| CHEMBL507129 | — | EC50 | = | 212.0 | nM | 6.67 |
| CHEMBL504663 | — | EC50 | = | 219.0 | nM | 6.66 |
| CHEMBL501339 | — | EC50 | = | 473.0 | nM | 6.33 |
| CHEMBL452873 | — | EC50 | - | — | - |