Assay Detail
Functional
CHEMBL953185
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1 NL432
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Combination of non-natural D-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV protease inhibitors have high efficacy in mutant HIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 7.61 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509787 | — | — | 1 | 8.03 |
| CHEMBL455816 | — | — | 1 | 7.80 |
| CHEMBL502912 | — | — | 1 | 7.77 |
| CHEMBL449552 | — | — | 1 | 7.77 |
| CHEMBL230484 | — | — | 1 | 7.77 |
| CHEMBL504713 | — | — | 1 | 7.77 |
| CHEMBL449213 | — | — | 1 | 7.75 |
| CHEMBL448032 | — | — | 1 | 7.70 |
| CHEMBL448021 | — | — | 1 | 7.70 |
| CHEMBL503829 | — | — | 1 | 7.66 |
| CHEMBL449945 | — | — | 1 | 7.66 |
| CHEMBL449836 | — | — | 1 | 7.64 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 7.60 |
| CHEMBL414640 | — | — | 1 | 7.44 |
| CHEMBL505525 | — | — | 1 | 7.11 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 7.10 |
| CHEMBL462726 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509787 | — | EC50 | = | 9.3 | nM | 8.03 |
| CHEMBL455816 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL502912 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL449552 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL230484 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL504713 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL449213 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL448032 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL448021 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL503829 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL449945 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL449836 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL414640 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL505525 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL163 | RITONAVIR | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL462726 | — | EC50 | = | 88.0 | nM | 7.06 |