Assay Detail
Functional
CHEMBL953188
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against ritonavir and nelfinavir-resistant HIV1 NL432
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Combination of non-natural D-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV protease inhibitors have high efficacy in mutant HIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 7.37 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509787 | — | — | 1 | 7.89 |
| CHEMBL230484 | — | — | 1 | 7.85 |
| CHEMBL462726 | — | — | 1 | 7.72 |
| CHEMBL449213 | — | — | 1 | 7.68 |
| CHEMBL449552 | — | — | 1 | 7.64 |
| CHEMBL455816 | — | — | 1 | 7.64 |
| CHEMBL449945 | — | — | 1 | 7.57 |
| CHEMBL502912 | — | — | 1 | 7.50 |
| CHEMBL504713 | — | — | 1 | 7.37 |
| CHEMBL449836 | — | — | 1 | 7.36 |
| CHEMBL448032 | — | — | 1 | 7.28 |
| CHEMBL448021 | — | — | 1 | 7.26 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 7.17 |
| CHEMBL503829 | — | — | 1 | 7.04 |
| CHEMBL505525 | — | — | 1 | 6.88 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 6.79 |
| CHEMBL414640 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509787 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL230484 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL462726 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL449213 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL449552 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL455816 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL449945 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL502912 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL504713 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL449836 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL448032 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL448021 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL503829 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL505525 | — | EC50 | = | 132.0 | nM | 6.88 |
| CHEMBL163 | RITONAVIR | EC50 | = | 162.0 | nM | 6.79 |
| CHEMBL414640 | — | EC50 | = | 237.0 | nM | 6.62 |