Assay Detail
Functional
CHEMBL953189
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Antiviral activity against HIV1 3B in presence of 10% fetal calf serum
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Combination of non-natural D-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV protease inhibitors have high efficacy in mutant HIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 7.82 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509787 | — | — | 1 | 8.40 |
| CHEMBL449552 | — | — | 1 | 8.10 |
| CHEMBL455816 | — | — | 1 | 8.03 |
| CHEMBL449945 | — | — | 1 | 7.92 |
| CHEMBL230484 | — | — | 1 | 7.89 |
| CHEMBL502912 | — | — | 1 | 7.85 |
| CHEMBL448032 | — | — | 1 | 7.85 |
| CHEMBL504713 | — | — | 1 | 7.85 |
| CHEMBL449213 | — | — | 1 | 7.80 |
| CHEMBL448021 | — | — | 1 | 7.75 |
| CHEMBL503829 | — | — | 1 | 7.70 |
| CHEMBL449836 | — | — | 1 | 7.70 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 7.68 |
| CHEMBL414640 | — | — | 1 | 7.66 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 7.62 |
| CHEMBL505525 | — | — | 1 | 7.60 |
| CHEMBL462726 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509787 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL449552 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL455816 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL449945 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL230484 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL502912 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL448032 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL504713 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL449213 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL448021 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL503829 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL449836 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL414640 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL163 | RITONAVIR | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL505525 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL462726 | — | EC50 | = | 27.0 | nM | 7.57 |