Assay Detail
Functional
CHEMBL953190
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B in presence of 10% fetal calf serum and alpha1 acid glycoprotein
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Combination of non-natural D-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV protease inhibitors have high efficacy in mutant HIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.73 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL449945 | — | — | 1 | 7.08 |
| CHEMBL449552 | — | — | 1 | 7.06 |
| CHEMBL448021 | — | — | 1 | 7.06 |
| CHEMBL503829 | — | — | 1 | 7.05 |
| CHEMBL230484 | — | — | 1 | 7.05 |
| CHEMBL455816 | — | — | 1 | 7.03 |
| CHEMBL502912 | — | — | 1 | 7.02 |
| CHEMBL449213 | — | — | 1 | 7.02 |
| CHEMBL504713 | — | — | 1 | 6.96 |
| CHEMBL505525 | — | — | 1 | 6.81 |
| CHEMBL449836 | — | — | 1 | 6.56 |
| CHEMBL509787 | — | — | 1 | 6.46 |
| CHEMBL448032 | — | — | 1 | 6.40 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 6.38 |
| CHEMBL414640 | — | — | 1 | 6.28 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 6.22 |
| CHEMBL462726 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL449945 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL449552 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL448021 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL503829 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL230484 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL455816 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL502912 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL449213 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL504713 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL505525 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL449836 | — | EC50 | = | 278.0 | nM | 6.56 |
| CHEMBL509787 | — | EC50 | = | 347.0 | nM | 6.46 |
| CHEMBL448032 | — | EC50 | = | 401.0 | nM | 6.40 |
| CHEMBL163 | RITONAVIR | EC50 | = | 422.0 | nM | 6.38 |
| CHEMBL414640 | — | EC50 | = | 529.0 | nM | 6.28 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 606.0 | nM | 6.22 |
| CHEMBL462726 | — | EC50 | = | 1268.0 | nM | 5.90 |