Assay Detail
Binding
CHEMBL953268
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Inhibition of PTP1B
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.98 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453868 | — | — | 1 | 6.28 |
| CHEMBL455694 | — | — | 1 | 5.52 |
| CHEMBL445194 | — | — | 1 | 5.40 |
| CHEMBL185726 | — | — | 1 | 5.30 |
| CHEMBL461734 | — | — | 1 | 5.22 |
| CHEMBL450560 | — | — | 1 | 4.89 |
| CHEMBL228563 | — | — | 1 | 4.72 |
| CHEMBL228397 | — | — | 1 | 4.70 |
| CHEMBL453899 | — | — | 1 | 4.52 |
| CHEMBL453874 | — | — | 1 | 4.50 |
| CHEMBL508948 | — | — | 1 | 4.47 |
| CHEMBL453861 | — | — | 1 | 4.19 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | - |
| CHEMBL455693 | — | — | 1 | - |
| CHEMBL509720 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453868 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL455694 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL445194 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL185726 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL461734 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL450560 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL228563 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL228397 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL453899 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL453874 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL508948 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL453861 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL165 | RESVERATROL | IC50 | > | 1000000.0 | nM | - |
| CHEMBL455693 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL509720 | — | IC50 | = | 194000.0 | nM | - |