Assay Detail
Binding
CHEMBL953269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TC-PTP
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 2 (CHEMBL3807) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.71 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453868 | — | — | 1 | 5.10 |
| CHEMBL445194 | — | — | 1 | 4.96 |
| CHEMBL185726 | — | — | 1 | 4.57 |
| CHEMBL461734 | — | — | 1 | 4.50 |
| CHEMBL455694 | — | — | 1 | 4.43 |
| CHEMBL228397 | — | — | 1 | - |
| CHEMBL228563 | — | — | 1 | - |
| CHEMBL508948 | — | — | 1 | - |
| CHEMBL453899 | — | — | 1 | - |
| CHEMBL450560 | — | — | 1 | - |
| CHEMBL453874 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453868 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL445194 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL185726 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL461734 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL455694 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL228397 | — | IC50 | = | 291000.0 | nM | - |
| CHEMBL228563 | — | IC50 | = | 156000.0 | nM | - |
| CHEMBL508948 | — | IC50 | = | 234000.0 | nM | - |
| CHEMBL453899 | — | IC50 | = | 173000.0 | nM | - |
| CHEMBL450560 | — | IC50 | = | 173000.0 | nM | - |
| CHEMBL453874 | — | IC50 | = | 567000.0 | nM | - |