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Assay Detail

CHEMBL953296

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MAGL-mediated [14C]1-oleoylglycerol hydrolysis in mouse brain
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Tissue Brain
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Monoglyceride lipase (CHEMBL5774)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.
Nomura DK, Hudak CS, Ward AM, Burston JJ, Issa RS, Fisher KJ, Abood ME, Wiley JL, Lichtman AH, Casida JE.
Bioorg Med Chem Lett (2008) 18 : 5875 -5878
PubMed 18752948 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.16 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL462582 1 7.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL462582 IC50 = 70.0 nM 7.16