Assay Detail
Binding
CHEMBL953321
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Low molecular weight protein-tyrosine phosphatase A (CHEMBL4542) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.54 | 5.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441861 | — | — | 1 | 5.08 |
| CHEMBL217931 | — | — | 1 | 4.64 |
| CHEMBL374279 | — | — | 1 | 4.40 |
| CHEMBL487051 | — | — | 1 | 4.29 |
| CHEMBL520906 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441861 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL217931 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL374279 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL487051 | — | IC50 | = | 50700.0 | nM | 4.29 |
| CHEMBL520906 | — | IC50 | = | 53700.0 | nM | 4.27 |