Assay Detail
Binding
CHEMBL953404
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Inhibition of Met kinase
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.90 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL525260 | — | — | 1 | 8.70 |
| CHEMBL524364 | — | — | 1 | 8.70 |
| CHEMBL502531 | — | — | 1 | 8.70 |
| CHEMBL500157 | — | — | 1 | 8.52 |
| CHEMBL499886 | — | — | 1 | 8.40 |
| CHEMBL525049 | — | — | 1 | 8.40 |
| CHEMBL526929 | — | — | 1 | 8.30 |
| CHEMBL499885 | — | — | 1 | 8.30 |
| CHEMBL500422 | — | — | 1 | 8.30 |
| CHEMBL502283 | — | — | 1 | 8.15 |
| CHEMBL502232 | — | — | 1 | 7.96 |
| CHEMBL508142 | — | — | 1 | 7.96 |
| CHEMBL502544 | — | — | 1 | 7.72 |
| CHEMBL527066 | — | — | 1 | 7.46 |
| CHEMBL499878 | — | — | 1 | 7.36 |
| CHEMBL500921 | — | — | 1 | 7.19 |
| CHEMBL499618 | — | — | 1 | 7.00 |
| CHEMBL503090 | — | — | 1 | 6.96 |
| CHEMBL253223 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL525260 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL524364 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL502531 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL500157 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL499886 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL525049 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL526929 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL499885 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL500422 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL502283 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL502232 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL508142 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL502544 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL527066 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL499878 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL500921 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL499618 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL503090 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL253223 | — | IC50 | = | 780.0 | nM | 6.11 |