Assay Detail
Functional
CHEMBL953405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human GTL16 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GTL 16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.70 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL524364 | — | — | 1 | 7.70 |
| CHEMBL500157 | — | — | 1 | 7.52 |
| CHEMBL525260 | — | — | 1 | 7.52 |
| CHEMBL502283 | — | — | 1 | 7.52 |
| CHEMBL502531 | — | — | 1 | 7.40 |
| CHEMBL500422 | — | — | 1 | 7.40 |
| CHEMBL503090 | — | — | 1 | 6.82 |
| CHEMBL499885 | — | — | 1 | 6.75 |
| CHEMBL499886 | — | — | 1 | 6.75 |
| CHEMBL525049 | — | — | 1 | 6.66 |
| CHEMBL526929 | — | — | 1 | 6.60 |
| CHEMBL527066 | — | — | 1 | 6.54 |
| CHEMBL502232 | — | — | 1 | 6.19 |
| CHEMBL499878 | — | — | 1 | 5.98 |
| CHEMBL500921 | — | — | 1 | 5.97 |
| CHEMBL502544 | — | — | 1 | 5.83 |
| CHEMBL499618 | — | — | 1 | 5.83 |
| CHEMBL508142 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL524364 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL500157 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL525260 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL502283 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL502531 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL500422 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL503090 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL499885 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL499886 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL525049 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL526929 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL527066 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL502232 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL499878 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL500921 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL502544 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL499618 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL508142 | — | IC50 | = | 2220.0 | nM | 5.65 |