Assay Detail
Functional
CHEMBL953479
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B in human CEM cells assessed as protection against virus-induced cytopathicity after 4 days
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 8.61 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL470630 | — | — | 1 | 9.00 |
| CHEMBL469985 | — | — | 1 | 9.00 |
| CHEMBL398174 | — | — | 1 | 9.00 |
| CHEMBL85059 | — | — | 1 | 8.96 |
| CHEMBL469986 | — | — | 1 | 8.96 |
| CHEMBL470007 | — | — | 1 | 8.85 |
| CHEMBL469569 | — | — | 1 | 8.82 |
| CHEMBL472217 | — | — | 1 | 8.80 |
| CHEMBL127012 | — | — | 1 | 8.80 |
| CHEMBL469562 | — | — | 1 | 8.72 |
| CHEMBL126603 | — | — | 1 | 8.72 |
| CHEMBL513080 | — | — | 1 | 8.70 |
| CHEMBL502565 | — | — | 1 | 8.64 |
| CHEMBL502297 | — | — | 1 | 8.64 |
| CHEMBL502566 | — | — | 1 | 8.64 |
| CHEMBL470403 | — | — | 1 | 8.62 |
| CHEMBL512673 | — | — | 1 | 8.59 |
| CHEMBL524360 | — | — | 1 | 8.57 |
| CHEMBL470404 | — | — | 1 | 8.51 |
| CHEMBL511963 | — | — | 1 | 8.43 |
| CHEMBL511290 | — | — | 1 | 8.42 |
| CHEMBL521183 | — | — | 1 | 8.41 |
| CHEMBL485180 | — | — | 1 | 8.38 |
| CHEMBL469804 | — | — | 1 | 8.34 |
| CHEMBL512486 | — | — | 1 | 8.29 |
| CHEMBL383700 | — | — | 1 | 8.19 |
| CHEMBL469358 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL470630 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL469985 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL398174 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL85059 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL469986 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL470007 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL469569 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL472217 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL127012 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL469562 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL126603 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL513080 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL502565 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL502297 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL502566 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL470403 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL512673 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL524360 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL470404 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL511963 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL511290 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL521183 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL485180 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL469804 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL512486 | — | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL383700 | — | EC50 | = | 6.4 | nM | 8.19 |
| CHEMBL469358 | — | EC50 | = | 26.0 | nM | 7.58 |