Assay Detail
Functional
CHEMBL953485
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 with reverse transcriptase K103N mutation in human CEM cells assessed as protection against virus-induced cytopathicity
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.20 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127012 | — | — | 1 | 7.85 |
| CHEMBL469985 | — | — | 1 | 7.72 |
| CHEMBL126603 | — | — | 1 | 7.54 |
| CHEMBL502565 | — | — | 1 | 7.44 |
| CHEMBL470007 | — | — | 1 | 7.40 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.89 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127012 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL469985 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL126603 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL502565 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL470007 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 2900.0 | nM | 5.54 |