Assay Detail
ADMET
CHEMBL953532
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Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies of curcumin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.51 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.52 |
| CHEMBL128748 | DIMETHYLCURCUMIN | 2.0 | 1 | 4.50 |
| CHEMBL521819 | — | — | 1 | - |
| CHEMBL492966 | — | — | 1 | - |
| CHEMBL522882 | — | — | 1 | - |
| CHEMBL180239 | CURCUMIN PYRAZOLE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL128748 | DIMETHYLCURCUMIN | IC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL521819 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL492966 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL522882 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL180239 | CURCUMIN PYRAZOLE | IC50 | > | 50000.0 | nM | - |