Assay Detail
Functional
CHEMBL953569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human alpha-1-beta-1-gamma-delta nAChR expressed in human TE671 cells by calcium influx assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TE-671 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Acetylcholine receptor; alpha1/beta1/delta/gamma (CHEMBL1907588) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.88 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL459689 | — | — | 1 | 5.40 |
| CHEMBL503427 | — | — | 1 | 5.20 |
| CHEMBL454407 | — | — | 1 | 4.90 |
| CHEMBL459900 | — | — | 1 | 4.00 |
| CHEMBL499536 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL459689 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL503427 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL454407 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL459900 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL499536 | — | IC50 | = | 125892.54 | nM | - |