Assay Detail

CHEMBL953891

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Functional

Antiviral activity against HIV1 R5 in human PBMC assessed as fractional inhibition of viral replication

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Rapamycin reduces CCR5 density levels on CD4 T cells, and this effect results in potentiation of enfuvirtide (T-20) against R5 strains of human immunodeficiency virus type 1 in vitro.

Heredia A, Gilliam B, Latinovic O, Le N, Bamba D, Devico A, Melikyan GB, Gallo RC, Redfield RR.
Antimicrob Agents Chemother (2007) 51 : 2489 -2496
PubMed 17485501 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	8.82	9.74

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL413	SIROLIMUS	4.0	1	9.74
CHEMBL525076	ENFUVIRTIDE	4.0	1	7.89

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL413	SIROLIMUS	EC50	=	0.18	nM	9.74
CHEMBL525076	ENFUVIRTIDE	EC50	=	12.93	nM	7.89