Assay Detail
Binding
CHEMBL953972
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Displacement of [3H]CP-55940 from human CB2 receptor
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel benzimidazole derivatives as selective CB2 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 53 | 7.66 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471129 | — | — | 1 | 9.00 |
| CHEMBL472506 | — | — | 1 | 8.80 |
| CHEMBL511134 | — | — | 1 | 8.55 |
| CHEMBL507572 | — | — | 1 | 8.55 |
| CHEMBL470965 | — | — | 1 | 8.43 |
| CHEMBL471374 | — | — | 1 | 8.41 |
| CHEMBL458142 | — | — | 1 | 8.40 |
| CHEMBL517283 | — | — | 1 | 8.40 |
| CHEMBL472157 | — | — | 1 | 8.39 |
| CHEMBL471980 | — | — | 1 | 8.35 |
| CHEMBL453846 | — | — | 1 | 8.35 |
| CHEMBL510072 | — | — | 1 | 8.31 |
| CHEMBL518206 | — | — | 1 | 8.30 |
| CHEMBL510854 | — | — | 1 | 8.25 |
| CHEMBL462533 | — | — | 1 | 8.24 |
| CHEMBL462330 | — | — | 1 | 8.23 |
| CHEMBL453844 | — | — | 1 | 8.16 |
| CHEMBL454607 | — | — | 1 | 8.12 |
| CHEMBL488310 | — | — | 1 | 8.05 |
| CHEMBL453842 | — | — | 1 | 7.96 |
| CHEMBL472121 | — | — | 1 | 7.96 |
| CHEMBL519592 | — | — | 1 | 7.92 |
| CHEMBL471992 | — | — | 1 | 7.92 |
| CHEMBL454864 | — | — | 1 | 7.85 |
| CHEMBL471558 | — | — | 1 | 7.82 |
| CHEMBL512906 | — | — | 1 | 7.80 |
| CHEMBL487629 | — | — | 1 | 7.77 |
| CHEMBL188 | WIN-552122 | — | 1 | 7.70 |
| CHEMBL512886 | — | — | 1 | 7.64 |
| CHEMBL451779 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471129 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL472506 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL507572 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL511134 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL470965 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL471374 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL458142 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL517283 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL472157 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL471980 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL453846 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL510072 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL518206 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL510854 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL462533 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL462330 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL453844 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL454607 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL488310 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL453842 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL472121 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL519592 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL471992 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL454864 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL471558 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL512906 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL487629 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL188 | WIN-552122 | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL512886 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL451779 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL453843 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL527208 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL487456 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL458143 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL472165 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL465 | DRONABINOL | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL462329 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL452803 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL453847 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL511021 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL488816 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL452039 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL454096 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL486440 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL461920 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL452804 | — | Ki | = | 526.0 | nM | 6.28 |
| CHEMBL471984 | — | Ki | = | 588.0 | nM | 6.23 |
| CHEMBL486438 | — | Ki | = | 799.0 | nM | 6.10 |
| CHEMBL461921 | — | Ki | = | 1349.0 | nM | 5.87 |
| CHEMBL469693 | — | Ki | = | 2920.0 | nM | 5.54 |