Assay Detail
Functional
CHEMBL953974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at cloned human CB2 receptor in Sf9 cells assessed as stimulation of [35S]GTPgammaS binding assay
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel benzimidazole derivatives as selective CB2 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 53 | 8.24 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL470965 | — | — | 1 | 9.28 |
| CHEMBL471129 | — | — | 1 | 9.15 |
| CHEMBL471374 | — | — | 1 | 9.00 |
| CHEMBL471992 | — | — | 1 | 8.96 |
| CHEMBL472506 | — | — | 1 | 8.89 |
| CHEMBL511134 | — | — | 1 | 8.89 |
| CHEMBL465 | DRONABINOL | 4.0 | 1 | 8.82 |
| CHEMBL507572 | — | — | 1 | 8.70 |
| CHEMBL462330 | — | — | 1 | 8.70 |
| CHEMBL510854 | — | — | 1 | 8.70 |
| CHEMBL472157 | — | — | 1 | 8.68 |
| CHEMBL488310 | — | — | 1 | 8.64 |
| CHEMBL453846 | — | — | 1 | 8.62 |
| CHEMBL518206 | — | — | 1 | 8.59 |
| CHEMBL517283 | — | — | 1 | 8.57 |
| CHEMBL471980 | — | — | 1 | 8.54 |
| CHEMBL453844 | — | — | 1 | 8.52 |
| CHEMBL454607 | — | — | 1 | 8.49 |
| CHEMBL510072 | — | — | 1 | 8.49 |
| CHEMBL472121 | — | — | 1 | 8.48 |
| CHEMBL458142 | — | — | 1 | 8.48 |
| CHEMBL519592 | — | — | 1 | 8.47 |
| CHEMBL453842 | — | — | 1 | 8.38 |
| CHEMBL471558 | — | — | 1 | 8.32 |
| CHEMBL512906 | — | — | 1 | 8.30 |
| CHEMBL454864 | — | — | 1 | 8.21 |
| CHEMBL462533 | — | — | 1 | 8.19 |
| CHEMBL487629 | — | — | 1 | 8.14 |
| CHEMBL512886 | — | — | 1 | 8.08 |
| CHEMBL451779 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL470965 | — | EC50 | = | 0.52 | nM | 9.28 |
| CHEMBL471129 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL471374 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL471992 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL472506 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL511134 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL465 | DRONABINOL | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL507572 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL462330 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL510854 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL472157 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL488310 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL453846 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL518206 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL517283 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL471980 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL453844 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL454607 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL510072 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL472121 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL458142 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL519592 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL453842 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL471558 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL512906 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL454864 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL462533 | — | EC50 | = | 6.4 | nM | 8.19 |
| CHEMBL487629 | — | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL512886 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL451779 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL487456 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL188 | WIN-552122 | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL452803 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL453843 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL453847 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL472165 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL527208 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL486440 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL462329 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL458143 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL511021 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL454096 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL452039 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL488816 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL471984 | — | EC50 | - | — | - | |
| CHEMBL469693 | — | EC50 | - | — | - | |
| CHEMBL486438 | — | EC50 | - | — | - | |
| CHEMBL452804 | — | EC50 | - | — | - | |
| CHEMBL510141 | — | EC50 | - | — | - | |
| CHEMBL461920 | — | EC50 | - | — | - |