Assay Detail
Binding
CHEMBL954028
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Inhibition of human factor 10a
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of imidazo[1,5-c]imidazol-3-ones: weakly basic, orally active factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.12 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487105 | — | — | 1 | 8.32 |
| CHEMBL487306 | — | — | 1 | 8.28 |
| CHEMBL485876 | — | — | 1 | 8.16 |
| CHEMBL259603 | — | — | 1 | 8.01 |
| CHEMBL486716 | — | — | 1 | 7.92 |
| CHEMBL519562 | — | — | 1 | 7.64 |
| CHEMBL484097 | — | — | 1 | 7.51 |
| CHEMBL514861 | — | — | 1 | 7.43 |
| CHEMBL519897 | — | — | 1 | 7.27 |
| CHEMBL521315 | — | — | 1 | 7.25 |
| CHEMBL477279 | — | — | 1 | 7.25 |
| CHEMBL483135 | — | — | 1 | 6.92 |
| CHEMBL484098 | — | — | 1 | 6.80 |
| CHEMBL486717 | — | — | 1 | 6.77 |
| CHEMBL482889 | — | — | 1 | 6.77 |
| CHEMBL482684 | — | — | 1 | 6.64 |
| CHEMBL488358 | — | — | 1 | 6.52 |
| CHEMBL478159 | — | — | 1 | 6.34 |
| CHEMBL514224 | — | — | 1 | 6.04 |
| CHEMBL482685 | — | — | 1 | 5.85 |
| CHEMBL482890 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487105 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL487306 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL485876 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL259603 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL486716 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL519562 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL484097 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL514861 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL519897 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL521315 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL477279 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL483135 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL484098 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL486717 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL482889 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL482684 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL488358 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL478159 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL514224 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL482685 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL482890 | — | IC50 | = | 1600.0 | nM | 5.80 |