Assay Detail
Functional
CHEMBL954077
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Ex vivo receptor occupancy by displacement of [3H]CP-55940 from rat CB1 receptor in po dosed rat cerebellum membrane after 3 hrs
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Cerebellum |
| Subcellular | Membrane |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Aminopyrazine CB1 receptor inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.66 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111 | RIMONABANT | 4.0 | 1 | 8.96 |
| CHEMBL497557 | — | — | 1 | 8.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111 | RIMONABANT | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL497557 | — | Ki | = | 4.4 | nM | 8.36 |