Assay Detail
Functional
CHEMBL954091
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Antagonist activity at human CB2 receptor in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS binding
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aminopyrazine CB1 receptor inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.71 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111 | RIMONABANT | 4.0 | 1 | 6.09 |
| CHEMBL496091 | — | — | 1 | 5.72 |
| CHEMBL497557 | — | — | 1 | 5.31 |
| CHEMBL498783 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111 | RIMONABANT | Ki | = | 815.0 | nM | 6.09 |
| CHEMBL496091 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL497557 | — | Ki | = | 4945.0 | nM | 5.31 |
| CHEMBL498783 | — | Ki | > | 50000.0 | nM | - |