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Assay Detail

CHEMBL954133

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of H+/K+ ATPase in New Zealand rabbit gastric gland assessed as 14C]-dimethylaminopyridine accumulation
19
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Spiro(imidazo[1,2-a]pyrano[2,3-c]pyridine-9-indenes) as inhibitors of gastric acid secretion.
Palmer AM, Chrismann S, Münch G, Brehm C, Zimmermann PJ, Buhr W, Senn-Bilfinger J, Feth MP, Simon WA.
Bioorg Med Chem (2009) 17 : 368 -384
PubMed 19026549 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.46 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL480408 1 7.00
CHEMBL465639 1 6.90
CHEMBL393803 1 6.70
CHEMBL520572 1 6.70
CHEMBL479817 1 6.70
CHEMBL479818 1 6.60
CHEMBL519612 1 6.60
CHEMBL464435 1 6.60
CHEMBL1162990 1 6.60
CHEMBL465087 2 6.60
CHEMBL518611 1 6.40
CHEMBL479816 1 6.40
CHEMBL464436 1 6.40
CHEMBL393804 1 6.30
CHEMBL480216 1 6.30
CHEMBL518603 1 6.10
CHEMBL481387 1 6.00
CHEMBL238686 1 5.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL480408 IC50 = 100.0 nM 7.00
CHEMBL465639 IC50 = 125.89 nM 6.90
CHEMBL393803 IC50 = 199.53 nM 6.70
CHEMBL520572 IC50 = 199.53 nM 6.70
CHEMBL479817 IC50 = 199.53 nM 6.70
CHEMBL479818 IC50 = 251.19 nM 6.60
CHEMBL519612 IC50 = 251.19 nM 6.60
CHEMBL464435 IC50 = 251.19 nM 6.60
CHEMBL1162990 IC50 = 251.19 nM 6.60
CHEMBL465087 IC50 = 251.19 nM 6.60
CHEMBL479816 IC50 = 398.11 nM 6.40
CHEMBL518611 IC50 = 398.11 nM 6.40
CHEMBL464436 IC50 = 398.11 nM 6.40
CHEMBL393804 IC50 = 501.19 nM 6.30
CHEMBL480216 IC50 = 501.19 nM 6.30
CHEMBL465087 IC50 = 630.96 nM 6.20
CHEMBL518603 IC50 = 794.33 nM 6.10
CHEMBL481387 IC50 = 1000.0 nM 6.00
CHEMBL238686 IC50 = 2511.89 nM 5.60