Assay Detail
Binding
CHEMBL954164
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Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 8.60 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462508 | — | — | 1 | 10.00 |
| CHEMBL496531 | — | — | 1 | 9.98 |
| CHEMBL495572 | — | — | 1 | 9.85 |
| CHEMBL339960 | — | — | 1 | 9.74 |
| CHEMBL461236 | — | — | 1 | 9.57 |
| CHEMBL126889 | — | — | 1 | 9.42 |
| CHEMBL497604 | — | — | 1 | 9.27 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.05 |
| CHEMBL497574 | — | — | 1 | 8.49 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 8.48 |
| CHEMBL497573 | — | — | 1 | 8.43 |
| CHEMBL496739 | — | — | 1 | 8.35 |
| CHEMBL517730 | — | — | 1 | 8.22 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.17 |
| CHEMBL497988 | — | — | 1 | 8.09 |
| CHEMBL495573 | — | — | 1 | 8.07 |
| CHEMBL522044 | — | — | 1 | 7.48 |
| CHEMBL461023 | — | — | 1 | 7.47 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.41 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462508 | — | Ki | = | 0.099 | nM | 10.00 |
| CHEMBL496531 | — | Ki | = | 0.105 | nM | 9.98 |
| CHEMBL495572 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL339960 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL461236 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL126889 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL497604 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL497574 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL497573 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL496739 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL517730 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL85 | RISPERIDONE | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL497988 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL495573 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL522044 | — | Ki | = | 32.92 | nM | 7.48 |
| CHEMBL461023 | — | Ki | = | 33.5 | nM | 7.47 |
| CHEMBL715 | OLANZAPINE | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL42 | CLOZAPINE | Ki | = | 319.0 | nM | 6.50 |