Compound Detail
CHEMBL497604
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Basic Information
| ChEMBL ID | CHEMBL497604 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AFUIBDRITZEBAF-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
402.5
MW (Da)
3.64
ALogP
5
HBA
1
HBD
72.5
PSA (Ų)
0.61
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 9.27
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(3) dopamine receptor CHEMBL234 | Ki | 9.27 | 9.27 | 0.5 | 1 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | Ki | 6.41 | 6.41 | 390.0 | 1 |
| D(2) dopamine receptor CHEMBL339 | Ki | 6.07 | 6.07 | 859.0 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 6.06 | 6.06 | 876.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(3) dopamine receptor | Ki | = | 0.54 | nM | 9.27 | Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by... | 19072656 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | Ki | = | 390.0 | nM | 6.41 | Binding affinity to human ERG expressed in HEK293 cells by whole cell patch clam... | 19072656 |
| D(2) dopamine receptor | Ki | = | 859.0 | nM | 6.07 | Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat... | 19072656 |
| 5-hydroxytryptamine receptor 1A | Ki | = | 876.0 | nM | 6.06 | Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippoc... | 19072656 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19072656 | 10.1021/jm800689g | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 19072656 | 10.1021/jm800689g | Unchecked | 1 |
| 19072656 | 10.1021/jm800689g | 5-hydroxytryptamine receptor 2A | 1 |
| 19072656 | 10.1021/jm800689g | 5-hydroxytryptamine receptor 1A | 1 |
| 19072656 | 10.1021/jm800689g | D(3) dopamine receptor | 1 |
| 19072656 | 10.1021/jm800689g | D(2) dopamine receptor | 1 |
| 19072656 | 10.1021/jm800689g | D(1A) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine