Assay Detail
Binding
CHEMBL954165
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Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.35 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497988 | — | — | 1 | 8.40 |
| CHEMBL462508 | — | — | 1 | 8.30 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 8.25 |
| CHEMBL496531 | — | — | 1 | 8.03 |
| CHEMBL496739 | — | — | 1 | 7.92 |
| CHEMBL461236 | — | — | 1 | 7.83 |
| CHEMBL495572 | — | — | 1 | 7.75 |
| CHEMBL522044 | — | — | 1 | 7.62 |
| CHEMBL461023 | — | — | 1 | 7.55 |
| CHEMBL495573 | — | — | 1 | 7.48 |
| CHEMBL517730 | — | — | 1 | 6.93 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.80 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 6.72 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 6.21 |
| CHEMBL497604 | — | — | 1 | 6.06 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.75 |
| CHEMBL497574 | — | — | 1 | - |
| CHEMBL497573 | — | — | 1 | - |
| CHEMBL126889 | — | — | 1 | - |
| CHEMBL339960 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497988 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL462508 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL496531 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL496739 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL461236 | — | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL495572 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL522044 | — | Ki | = | 24.2 | nM | 7.62 |
| CHEMBL461023 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL495573 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL517730 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL42 | CLOZAPINE | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL85 | RISPERIDONE | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL715 | OLANZAPINE | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL497604 | — | Ki | = | 876.0 | nM | 6.06 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL497574 | — | Ki | - | — | - | |
| CHEMBL497573 | — | Ki | - | — | - | |
| CHEMBL126889 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL339960 | — | Ki | > | 10000.0 | nM | - |