Assay Detail
Binding
CHEMBL954167
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]mesulergine from 5HT2C receptor in CRL:(HA) BR albino guinea pig cortex by scintillation spectrometry
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.94 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 8.39 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.32 |
| CHEMBL496531 | — | — | 1 | 7.74 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 7.66 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.50 |
| CHEMBL462508 | — | — | 1 | 6.87 |
| CHEMBL495572 | — | — | 1 | 6.81 |
| CHEMBL461236 | — | — | 1 | 6.76 |
| CHEMBL496739 | — | — | 1 | 6.69 |
| CHEMBL517730 | — | — | 1 | 6.36 |
| CHEMBL461023 | — | — | 1 | 5.96 |
| CHEMBL495573 | — | — | 1 | 5.87 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.33 |
| CHEMBL497988 | — | — | 1 | - |
| CHEMBL522044 | — | — | 1 | - |
| CHEMBL497574 | — | — | 1 | - |
| CHEMBL497573 | — | — | 1 | - |
| CHEMBL497604 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL42 | CLOZAPINE | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL496531 | — | Ki | = | 18.4 | nM | 7.74 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL85 | RISPERIDONE | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL462508 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL495572 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL461236 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL496739 | — | Ki | = | 206.0 | nM | 6.69 |
| CHEMBL517730 | — | Ki | = | 434.0 | nM | 6.36 |
| CHEMBL461023 | — | Ki | = | 1086.0 | nM | 5.96 |
| CHEMBL495573 | — | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL497988 | — | Ki | - | — | - | |
| CHEMBL522044 | — | Ki | - | — | - | |
| CHEMBL497574 | — | Ki | - | — | - | |
| CHEMBL497573 | — | Ki | - | — | - | |
| CHEMBL497604 | — | Ki | - | — | - |