Assay Detail
Functional
CHEMBL954254
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Antiviral activity against HIV1 with reverse transcriptase Y188L mutation in human CEM cells assessed as protection against virus-induced cytopathicity
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.15 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127012 | — | — | 1 | 6.18 |
| CHEMBL126603 | — | — | 1 | 6.16 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.12 |
| CHEMBL469985 | — | — | 1 | - |
| CHEMBL470007 | — | — | 1 | - |
| CHEMBL502565 | — | — | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127012 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL126603 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL469985 | — | IC50 | >= | 1000.0 | nM | - |
| CHEMBL470007 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL502565 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | IC50 | > | 10000.0 | nM | - |