Assay Detail
Binding
CHEMBL954312
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Inhibition of matriptase
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Suppressor of tumorigenicity 14 protein (CHEMBL3018) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Incorporation of neutral C-terminal residues in 3-amidinophenylalanine-derived matriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.25 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378657 | — | — | 1 | 8.74 |
| CHEMBL498875 | — | — | 1 | 8.21 |
| CHEMBL444411 | — | — | 1 | 8.20 |
| CHEMBL507322 | — | — | 1 | 8.12 |
| CHEMBL492342 | — | — | 1 | 7.92 |
| CHEMBL493116 | — | — | 1 | 7.89 |
| CHEMBL445195 | — | — | 1 | 7.77 |
| CHEMBL493936 | — | — | 1 | 7.51 |
| CHEMBL493117 | — | — | 1 | 7.48 |
| CHEMBL493118 | — | — | 1 | 7.43 |
| CHEMBL493520 | — | — | 1 | 7.28 |
| CHEMBL443990 | — | — | 1 | 7.28 |
| CHEMBL523865 | — | — | 1 | 7.19 |
| CHEMBL492333 | — | — | 1 | 7.00 |
| CHEMBL506479 | — | — | 1 | 6.82 |
| CHEMBL494128 | — | — | 1 | 6.75 |
| CHEMBL495143 | — | — | 1 | 6.59 |
| CHEMBL493140 | — | — | 1 | 6.33 |
| CHEMBL492334 | — | — | 1 | 5.62 |
| CHEMBL495010 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378657 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL498875 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL444411 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL507322 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL492342 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL493116 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL445195 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL493936 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL493117 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL493118 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL493520 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL443990 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL523865 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL492333 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL506479 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL494128 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL495143 | — | Ki | = | 255.0 | nM | 6.59 |
| CHEMBL493140 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL492334 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL495010 | — | Ki | = | 11000.0 | nM | 4.96 |