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Assay Detail

CHEMBL954313

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Binding
Inhibition of factor 10a
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Incorporation of neutral C-terminal residues in 3-amidinophenylalanine-derived matriptase inhibitors.
Schweinitz A, Dönnecke D, Ludwig A, Steinmetzer P, Schulze A, Kotthaus J, Wein S, Clement B, Steinmetzer T.
Bioorg Med Chem Lett (2009) 19 : 1960 -1965
PubMed 19250826 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 5.13 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL492333 1 7.00
CHEMBL493118 1 5.68
CHEMBL493116 1 5.60
CHEMBL506479 1 5.60
CHEMBL445195 1 5.47
CHEMBL493520 1 5.36
CHEMBL498875 1 5.21
CHEMBL492342 1 5.09
CHEMBL378657 1 5.02
CHEMBL493117 1 5.00
CHEMBL444411 1 5.00
CHEMBL494128 1 4.96
CHEMBL493936 1 4.82
CHEMBL493140 1 4.77
CHEMBL495143 1 4.75
CHEMBL507322 1 4.72
CHEMBL523865 1 4.58
CHEMBL495010 1 4.52
CHEMBL443990 1 4.36
CHEMBL492334 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL492333 Ki = 100.0 nM 7.00
CHEMBL493118 Ki = 2100.0 nM 5.68
CHEMBL493116 Ki = 2500.0 nM 5.60
CHEMBL506479 Ki = 2500.0 nM 5.60
CHEMBL445195 Ki = 3400.0 nM 5.47
CHEMBL493520 Ki = 4400.0 nM 5.36
CHEMBL498875 Ki = 6100.0 nM 5.21
CHEMBL492342 Ki = 8200.0 nM 5.09
CHEMBL378657 Ki = 9500.0 nM 5.02
CHEMBL493117 Ki = 10000.0 nM 5.00
CHEMBL444411 Ki = 10000.0 nM 5.00
CHEMBL494128 Ki = 11000.0 nM 4.96
CHEMBL493936 Ki = 15000.0 nM 4.82
CHEMBL493140 Ki = 17000.0 nM 4.77
CHEMBL495143 Ki = 18000.0 nM 4.75
CHEMBL507322 Ki = 19000.0 nM 4.72
CHEMBL523865 Ki = 26000.0 nM 4.58
CHEMBL495010 Ki = 30000.0 nM 4.52
CHEMBL443990 Ki = 44000.0 nM 4.36
CHEMBL492334 Ki = 127000.0 nM -