Assay Detail
Functional
CHEMBL954364
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Inhibition of PMA-stimulated super oxide anion generation in Sprague-Dawley rat neutrophils
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, anti-inflammatory, and antioxidant activities of 18beta-glycyrrhetinic acid derivatives as chemical mediators and xanthine oxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.06 | 5.75 |
| Inhibition | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL397686 | DIPHENYLENEIODONIUM CHLORIDE | — | 2 | 5.75 |
| CHEMBL492918 | — | — | 2 | 4.89 |
| CHEMBL508226 | — | — | 2 | 4.81 |
| CHEMBL508447 | — | — | 2 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL397686 | DIPHENYLENEIODONIUM CHLORIDE | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL492918 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL508226 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL508447 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL492918 | — | Inhibition | - | % | - | |
| CHEMBL508447 | — | Inhibition | - | % | - | |
| CHEMBL508226 | — | Inhibition | - | % | - | |
| CHEMBL397686 | DIPHENYLENEIODONIUM CHLORIDE | Inhibition | - | % | - |