Assay Detail
Functional
CHEMBL954365
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Inhibition of LPS-induced nitric oxide generation in mouse RAW264.7 cells pretreated 1 hr before LPS challenge by Griess method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, anti-inflammatory, and antioxidant activities of 18beta-glycyrrhetinic acid derivatives as chemical mediators and xanthine oxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.35 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107251 | 1400W | — | 1 | 5.82 |
| CHEMBL508226 | — | — | 1 | 4.88 |
| CHEMBL493512 | — | — | 1 | - |
| CHEMBL522515 | — | — | 1 | - |
| CHEMBL438331 | — | — | 1 | - |
| CHEMBL508447 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107251 | 1400W | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL508226 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL493512 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL522515 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL438331 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL508447 | — | IC50 | > | 30000.0 | nM | - |