Assay Detail
Functional
CHEMBL954499
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Growth inhibition of IL-6-independent mouse MH60 cells after 72 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | MH60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibitory effects of bufadienolides on interleukin-6 in MH-60 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.82 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486200 | — | — | 1 | 5.37 |
| CHEMBL486201 | — | — | 1 | 5.08 |
| CHEMBL451719 | — | — | 1 | 5.08 |
| CHEMBL455362 | — | — | 1 | 4.89 |
| CHEMBL486613 | — | — | 1 | 4.76 |
| CHEMBL454990 | — | — | 1 | 4.72 |
| CHEMBL518900 | — | — | 1 | 4.66 |
| CHEMBL449210 | — | — | 1 | 4.47 |
| CHEMBL485810 | — | — | 1 | 4.35 |
| CHEMBL501866 | — | — | 1 | - |
| CHEMBL452684 | — | — | 1 | - |
| CHEMBL485820 | — | — | 1 | - |
| CHEMBL519412 | — | — | 1 | - |
| CHEMBL486614 | — | — | 1 | - |
| CHEMBL463064 | BUFOTALIN | — | 1 | - |
| CHEMBL250785 | CINOBUFAGIN | — | 1 | - |
| CHEMBL487004 | — | — | 1 | - |
| CHEMBL455361 | — | — | 1 | - |
| CHEMBL401421 | — | — | 1 | - |
| CHEMBL486810 | — | — | 1 | - |
| CHEMBL508301 | — | — | 1 | - |
| CHEMBL510534 | — | — | 1 | - |
| CHEMBL521034 | — | — | 1 | - |
| CHEMBL399680 | BUFALIN | — | 1 | - |
| CHEMBL250172 | BUFOGENIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486200 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL486201 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL451719 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL455362 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL486613 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL454990 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL518900 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL449210 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL485810 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL501866 | — | IC50 | > | 53200.0 | nM | - |
| CHEMBL452684 | — | IC50 | > | 53200.0 | nM | - |
| CHEMBL485820 | — | IC50 | > | 54200.0 | nM | - |
| CHEMBL519412 | — | IC50 | > | 54200.0 | nM | - |
| CHEMBL486614 | — | IC50 | > | 54800.0 | nM | - |
| CHEMBL463064 | BUFOTALIN | IC50 | > | 56200.0 | nM | - |
| CHEMBL250785 | CINOBUFAGIN | IC50 | > | 56300.0 | nM | - |
| CHEMBL487004 | — | IC50 | > | 56600.0 | nM | - |
| CHEMBL455361 | — | IC50 | > | 58400.0 | nM | - |
| CHEMBL401421 | — | IC50 | > | 58700.0 | nM | - |
| CHEMBL486810 | — | IC50 | > | 60700.0 | nM | - |
| CHEMBL508301 | — | IC50 | > | 62200.0 | nM | - |
| CHEMBL510534 | — | IC50 | > | 62200.0 | nM | - |
| CHEMBL521034 | — | IC50 | > | 62500.0 | nM | - |
| CHEMBL399680 | BUFALIN | IC50 | > | 64800.0 | nM | - |
| CHEMBL250172 | BUFOGENIN | IC50 | > | 65100.0 | nM | - |