Assay Detail
Functional
CHEMBL954500
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of IL6-dependent mouse MH60 cells after 72 hrs by MTT assay in presence of human recombinant IL6
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | MH60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibitory effects of bufadienolides on interleukin-6 in MH-60 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.09 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486200 | — | — | 1 | 5.89 |
| CHEMBL486613 | — | — | 1 | 5.70 |
| CHEMBL451719 | — | — | 1 | 5.62 |
| CHEMBL486201 | — | — | 1 | 5.37 |
| CHEMBL487004 | — | — | 1 | 5.28 |
| CHEMBL455362 | — | — | 1 | 5.25 |
| CHEMBL454990 | — | — | 1 | 5.19 |
| CHEMBL452684 | — | — | 1 | 5.17 |
| CHEMBL455361 | — | — | 1 | 5.05 |
| CHEMBL486614 | — | — | 1 | 5.03 |
| CHEMBL501866 | — | — | 1 | 4.94 |
| CHEMBL518900 | — | — | 1 | 4.84 |
| CHEMBL449210 | — | — | 1 | 4.74 |
| CHEMBL485810 | — | — | 1 | 4.74 |
| CHEMBL250172 | BUFOGENIN | 2.0 | 1 | 4.64 |
| CHEMBL521034 | — | — | 1 | 4.61 |
| CHEMBL399680 | BUFALIN | — | 1 | 4.50 |
| CHEMBL485820 | — | — | 1 | - |
| CHEMBL519412 | — | — | 1 | - |
| CHEMBL463064 | BUFOTALIN | — | 1 | - |
| CHEMBL250785 | CINOBUFAGIN | — | 1 | - |
| CHEMBL401421 | — | — | 1 | - |
| CHEMBL486810 | — | — | 1 | - |
| CHEMBL508301 | — | — | 1 | - |
| CHEMBL510534 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486200 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL486613 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL451719 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL486201 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL487004 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL455362 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL454990 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL452684 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL455361 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL486614 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL501866 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL518900 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL449210 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL485810 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL250172 | BUFOGENIN | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL521034 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL399680 | BUFALIN | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL485820 | — | IC50 | > | 54200.0 | nM | - |
| CHEMBL519412 | — | IC50 | > | 54200.0 | nM | - |
| CHEMBL463064 | BUFOTALIN | IC50 | > | 56200.0 | nM | - |
| CHEMBL250785 | CINOBUFAGIN | IC50 | > | 56300.0 | nM | - |
| CHEMBL401421 | — | IC50 | > | 58700.0 | nM | - |
| CHEMBL486810 | — | IC50 | > | 60700.0 | nM | - |
| CHEMBL508301 | — | IC50 | > | 62200.0 | nM | - |
| CHEMBL510534 | — | IC50 | > | 62200.0 | nM | - |