Assay Detail
Functional
CHEMBL954871
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Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.72 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.14 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.89 |
| CHEMBL182739 | — | — | 1 | 8.48 |
| CHEMBL526314 | — | — | 1 | 8.11 |
| CHEMBL505905 | — | — | 1 | 8.04 |
| CHEMBL499306 | — | — | 1 | 7.94 |
| CHEMBL452048 | — | — | 1 | 7.92 |
| CHEMBL506674 | — | — | 1 | 7.88 |
| CHEMBL493809 | — | — | 1 | 7.78 |
| CHEMBL506035 | — | — | 1 | 7.53 |
| CHEMBL447545 | — | — | 1 | 7.53 |
| CHEMBL443720 | — | — | 1 | 7.51 |
| CHEMBL525400 | — | — | 1 | 7.43 |
| CHEMBL499848 | — | — | 1 | 7.36 |
| CHEMBL275497 | — | — | 1 | 7.36 |
| CHEMBL493808 | — | — | 1 | 7.25 |
| CHEMBL493978 | — | — | 1 | 7.11 |
| CHEMBL499027 | — | — | 1 | 6.85 |
| CHEMBL497753 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL182739 | — | IC50 | = | 3.33 | nM | 8.48 |
| CHEMBL526314 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL505905 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL499306 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL452048 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL506674 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL493809 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL506035 | — | IC50 | = | 29.6 | nM | 7.53 |
| CHEMBL447545 | — | IC50 | = | 29.7 | nM | 7.53 |
| CHEMBL443720 | — | IC50 | = | 31.1 | nM | 7.51 |
| CHEMBL525400 | — | IC50 | = | 37.5 | nM | 7.43 |
| CHEMBL499848 | — | IC50 | = | 44.2 | nM | 7.36 |
| CHEMBL275497 | — | IC50 | = | 43.4 | nM | 7.36 |
| CHEMBL493808 | — | IC50 | = | 56.2 | nM | 7.25 |
| CHEMBL493978 | — | IC50 | = | 77.8 | nM | 7.11 |
| CHEMBL499027 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL497753 | — | IC50 | = | 228.9 | nM | 6.64 |